Translocation [electronic resource] : movement of tRNA and mRNA through the ribosome / Harry F. Noller.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Mechanisms of ribosome function : insights into protein synthesis: Publisher: London : Henry Stewart Talks, 2008Description: 1 online resource (1 streaming video file (41 min.) : color, sound)Subject(s): Protein Biosynthesis | Ribosomal Proteins | RibosomesOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Ribosomes and translation -- Molecular composition of the ribosome -- Why is the ribosome so big? -- The mRNA channel in the 30S subunit -- Positions of tRNA in the A-, P- and E-sites -- Structural dynamics of the ribosome during translocation -- The hybrid states elongation cycle -- tRNA binding during its movement through the ribosome -- The 70S ribosome -- Distortion of tRNA structure by the ribosome -- The ratchet model -- Cryo-EM experiment -- Inferred relationship between ratcheting and hybrid states -- FRET changes -- Intersubunit movement -- Testing the ratchet model for translocation -- Translocation assay -- What defines the mechanism of translocation -- Sparsomycin -- The energetics of translocation -- E-site tRNA -- The ribosome is a molecular machine.
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Mode of access: World Wide Web.