CD44 genetic deletion enhances and CD44 antibody targeting attenuates autoimmune inflammation [electronic resource] / Itahk Golan ... [et al.]
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FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Autoimmunity : etiology, pathogenesis, clinical manifestation and diagnostic methodologies: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (32 min.) : color, sound)Subject(s): Autoimmune Diseases | Autoimmunity | ResearchOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
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Contents: CD44 and RHAMM (receptor for hyaluronan-mediated motility) are cell adhesion and cell homing receptors -- Cell migration -- Generation of different CD44 isoforms -- RHAMM also supports cell motility and is engaged in intracellular signalling -- Collagen-induced arthritis and type 1 diabetes are CD44-dependent pathologies -- Molecular redundancy -- CD44 targeting by anti-CD44 mAb may eradicate not only malignant cells and destructive inflammatory cells but also CD44-expressing normal cells which are committed to physiological functions.
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Mode of access: World Wide Web.