Antibody engineering of Fc effector functions [electronic resource] / Mike Clark.Material type: FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Monoclonal antibodies as therapeutic agents : fundamentals, therapeutic applications and latest advances: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (57 min.) : color, sound)Subject(s): Antibodies, Monoclonal -- therapeutic use | Receptors, FcOnline resources: Click here to access online | Series
Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: IgG structure and modes of action -- Human IgG Fc receptors -- Structural interactions -- Engineering strategy -- Selection of subclasses and effector functions -- Manipulation of functions -- Case study: FMAIT -- Design and engineering of inhibitory Fc mutants -- Functional properties -- Complement mediated lysis -- FcR binding -- Monocyte activation -- ADCC -- Clinical volunteer study -- Activatory mutations -- Enhanced binding to FcR -- Increased ADCC -- Possible applications.
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Mode of access: World Wide Web.