Molecular epidemiology of lung cancer [electronic resource] / David C. Christiani.

By: Christiani, David C [spk]Material type: FilmFilmSeries: Henry Stewart talksBiomedical & life sciences collection. Gene-environment interactions : role in the modulation of pulmonary and autoimmune disease risks: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (40 min.) : color, sound)Subject(s): Environmental Exposure | Genes | Genetic Predisposition to Disease | Risk FactorsOnline resources: Click here to access online | Series
Contents:
Contents: The influence of host factors on individual susceptibility to tobacco smoke -- The pleiotropic genes that control activation (Phase I) and detoxification (Phase II) of potential carcinogens -- Effects of the metabolism of environmental compounds on the lipophilic properties of a molecule and the introduction of electronegative moieties within the molecule on carcinogenic potential -- Other susceptibility factors related to defects in DNA repair, alterations in tumor suppressor genes and alterations in tumor invasiveness factors -- Polymorphisms in genes and the association of this with lung cancer development -- The role of inherited polymorphisms of genes involved in xenobiotic metabolism, DNA repair and tumor suppression/invasion (alone and in combination) in lung cancer risk, and modification of this risk by environmental factors such as smoking and diet.
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Contents: The influence of host factors on individual susceptibility to tobacco smoke -- The pleiotropic genes that control activation (Phase I) and detoxification (Phase II) of potential carcinogens -- Effects of the metabolism of environmental compounds on the lipophilic properties of a molecule and the introduction of electronegative moieties within the molecule on carcinogenic potential -- Other susceptibility factors related to defects in DNA repair, alterations in tumor suppressor genes and alterations in tumor invasiveness factors -- Polymorphisms in genes and the association of this with lung cancer development -- The role of inherited polymorphisms of genes involved in xenobiotic metabolism, DNA repair and tumor suppression/invasion (alone and in combination) in lung cancer risk, and modification of this risk by environmental factors such as smoking and diet.

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