Therapeutic delivery of RNAi [electronic resource] / Patrick Y. Lu.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. RNA interference : principles and applications: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (37 min.) : color, sound)Other title: Therapeutic delivery of RNA interferenceSubject(s): RNA InterferenceOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: RNAi therapeutics development -- RNAi cellular activity -- In vivo siRNA delivery is key -- Clinically viable siRNA deliveries -- Local delivery of siRNA -- Gene silencing in tumors -- Cancer target validation in vivo -- RNAi effects in mouse brain, joints, eyes and lungs -- siRNA therapeutics in primate models -- Challenges to siRNA systemic delivery -- Systemic delivery technology -- Targeted nanoparticle siRNA delivery -- Self assembled nanoparticle -- Integrin av-beta is a validated target -- Dual-targeted therapeutic approach -- Neovasculature targeting siRNA -- Multi-targeted anti-angiogenesis -- Efficient targeted systemic delivery -- Systemic siRNA delivery to eyes -- Systemic siRNA delivery for neuroblastoma treatment -- Tumor neovasculature inhibition -- siRNA/Atelocollagen anti-tumor efficacy -- Transferrin-mediated systemic delivery -- Antibody-mediated tumor targeting -- Targeted anti-HBV activity -- RNAi effect of chol-siRNA -- PEI-mediated siRNA lung targeting -- Clinicallyviable delivery is the key for successful siRNA therapeutics.
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Mode of access: World Wide Web.