Nonsense-mediated and Staufen1-mediated mRNA decay [electronic resource] : related pathways of post-transcriptional control in mammalian cells / Lynne E. Maquat.
Material type:![Film](/opac-tmpl/lib/famfamfam/VM.png)
Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Three core Upf NMD factors -- Exon junction complexes (EJCs) -- Upf1 -- Mechanism of NMD -- Activation of EJC-bound Upf1 -- Role of NMD in downregulating spliced mRNAs to eliminate truncated proteins -- NMD downregulating functional protein isoforms -- Restriction to newly synthesized mRNAs during a pioneer round of translation -- Cap Binding Protein (CBP) heterodimer CBP80-CBP20 -- Eukaryotic translation initiation factor (eIF) 4E and steady state mRNA -- Role of CBP80 in enhancing efficiency of NMD by promoting the interaction of Upf1 with EJC-bound Upf2 -- Staufen (Stau)1-mediated mRNA decay (SMD) -- Double-stranded RNA binding protein Stau1 -- Mechanism of action of SMD.
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Mode of access: World Wide Web.