A historical perspective on ideas on X-chromosome inactivation [electronic resource] / Mary Lyon.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (34 min.) : color, sound)Subject(s): Epigenesis, Genetic | X Chromosome InactivationOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: The phenomenon of X-chromosome inactivation in female mammals -- X-chromosome inactivation as a dosage compensation mechanism for equalising the dosage of X-linked gene products in XY males and XX females in somatic cells -- inactivity of either the maternal or paternal X-chromosome in different cells in eutherian mammals -- preferential inactivation of paternal X in the placenta of mice and in all cells of marsupials -- initiation of the process from an X-inactivation centre -- discovery of the key gene, Xist -- the concept of initiation and maintenance of X-inactivation as separate processes -- histone modifications and methylation of CpG islands as maintenance mechanisms -- inactivation in autosomal and X-chromosomal DNA -- LINE1s as booster elements on the X-chromosome.
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Mode of access: World Wide Web.