Pharmacokinetics, toxicokinetics & safety margins [electronic resource] / Mark C. Rogge.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Non-clinical testing for toxicity of pharmaceuticals: Publisher: London : Henry Stewart Talks, 2009Description: 1 online resource (1 streaming video file (43 min.) : color, sound)Other title: Pharmacokinetics, toxicokinetics and safety marginsSubject(s): Drug Toxicity | Toxicity TestsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchonized narration.
Title from title frames.
Contents: The pharmacologic and toxic effects of a potential therapeutic agent are a consequence of the product concentration at the site of action -- By understanding inter-species sensitivity to the agent and to the absorption and disposition properties, a rational first in human dose can be determined -- Basic pharmacokinetic elements -- Measures of exposure -- Scaling methods and calculations of relative exposure -- Utilizing outcomes from toxicology evaluations and associated exposure measures -- First in human dose concept.
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Mode of access: World Wide Web.