Protein Tyrosine Phosphatases [electronic resource] / Jack Dixon.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Protein phosphorylation: Publisher: London : Henry Stewart Talks, 2010Description: 1 online resource (1 streaming video file (45 min.) : color, sound)Subject(s): Phosphorylation | Protein Tyrosine PhosphatasesOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Kinases and phosphatases -- Ways to remove phosphate from proteins -- Class I Cys-based PTPs -- Phosphatase families -- Mutational analysis of PTP-1 -- Sequences at active site -- Phospho-enzyme intermediate -- pH stability of phosphoprotein phosphate -- Site-directed mutational analysis of VHR -- How PTPs share a catalytic active site motif -- Sequences of phosphatases -- The bacterial Yop 2b phosphatase activity -- Bacterial growth in the spleen of mice -- Yop 2b in eukaryotic macrophages -- Interaction between Yersinia and a target cell -- Phosphatases as tumor suppressor genes -- PTEN and myotubularin structure -- PTEN-10q23.3 -- Frequency of PTEN mutations -- Kinetic constants of dual-specificity phosphates -- How PTEN is a "lipid" phosphatase -- How PTEN might inhibit cell survival -- Effect of PTEN overexpression on PIP3 production -- Effect of PTEN expression on PI 3-kinase activation -- Inositol phosphatase activity of PTEN -- PTEN tumor suppressor activity -- Key PTEN and PIP3 researchers -RNA interference in C.elegans -- RNA interference protocol for fly S2 cells -- Mammalian, C.elegans and fly signaling cascade -- How PTEN inhibits Akt activity -- The active site pocket of PTEN -- Sequence alignment of PTEN catalytic site.
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Mode of access: World Wide Web.