A paradigm shift in the brain-immune relationships [electronic resource] : infiltrating macrophages in central nervous system repair / Michal Schwartz.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Macrophage heterogeneity and function: Publisher: London : Henry Stewart Talks, 2013Description: 1 online resource (1 streaming video file (71 min.) : color, sound)Subject(s): Brain -- Immunology | Central nervous system -- Immunology | Macrophages | Brain -- immunology | Central Nervous System -- immunology | Immune System -- physiology | MacrophagesOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Contents: The CNS immune enigma -- CNS response to injury -- Recruitment of macrophages is insufficient -- Site, dose, timing for macrophage implantation -- Local and systemic immune response -- Circulating T cells are needed for recovery -- Protective autoimmunity vs. autoimmune disease -- Two faces of macrophages -- Creation of chimeric mice with head protection -- Macrophages play anti-inflammatory role -- Transferred monocytes promote repair -- T-cells boost monocyte recruitment -- Macrophages resolve microglia response -- The glial scar regulates microglia / macrophages -- CSPG production and degradation -- CSPG and the IL-10 expressing monocytes -- Co-localization of macrophages with the glial scar -- Location determines macrophage phenotype -- Macrophages and neuroprotection in the retina -- Macrophages support progenitor cell renewal -- Monocyte recruitment is limited -- Type, phenotype, location, timing -- Neurogenesis: highest manifestation of plasticity -- CNS specific autoreactive T cells -- Spatial memory -- The immunological malfunction -- Immunity to self and self-maintenance -- Local and systemic inflammation -- Circulating cells fight local inflammation -- Recruitment of monocytes in Alzheimer -- From immune deficiency to brain malfunction.
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Mode of access: World Wide Web.