Host genetic factors that limit HIV and AIDS [electronic resource] / Cheryl A. Winkler.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection: Publisher: London : Henry Stewart Talks, 2013Description: 1 online resource (1 streaming video file (54 min.) : color, sound)Subject(s): AIDS (Disease) -- Genetic aspects | HIV infections | Acquired Immunodeficiency Syndrome -- genetics | Acquired Immunodeficiency Syndrome -- immunology | Genome-Wide Association Study | HIV Infections -- genetics | HIV Infections -- immunologyOnline resources: Click here to access online Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Overview of candidate gene association studies of HIV and AIDS -- Key role for genetic variants involved in cell entry and host defenses -- Homozygous CCR5 32 basepair deletion prevents HIV Infection -- Acquired Immunity: HLA Class 1 proteins -- Key mediators of HIV progression -- Innate Protection: HLA and KIRS interactions in HIV disease -- Overview of Genome Wide Association Studies (GWAS) -- Overwhelming influence of HLA class I on HIV Progression and control of HIV viral load -- Non-HLA genetic associations with extreme phenotypes -- No new variants identified that prevent HIV infection -- Discovery of chromosome 22 associations with HIV-associated nephropathy -- Future studies -- Epigenetic, proteomic, functional studies -- Potential role of rare variants.
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Mode of access: World Wide Web.