Intestinal stem cell-mediated repair in Drosophila [electronic resource] : Part 2 of 2 / Tony Ip.
Material type:![Film](/opac-tmpl/lib/famfamfam/VM.png)
Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: The adult Drosophila midgut contains tissue specific intestinal stem cells (ISCs) -- ISCs are the only dividing cells in the midgut and are responsible for maintaining midgut homeostasis and regeneration -- The ISC division gives rise to a renewed stem cell and an enteroblast, which can differentiate into secretory enteroendocrine cells or absorptive enterocytes -- Intrinsic factors such as Tuberous Sclerosis Complex and Myc coordinate the growth and division of ISCs -- Extrinsic factors such as Epidermal Growth Factor from surrounding cells and the interaction with basement membrane also regulate the rate of ISC division -- Insulin secreted from CNS function as a long-range growth factor to control ISC activity and therefore intestinal tissue homeostasis.
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Mode of access: World Wide Web.