Intestinal stem cell-mediated repair in Drosophila [electronic resource] : part 1 of 2 / Tony Ip.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Legacy of Drosophila genetics : from 'defining the gene' to 'analyzing genome function': Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (34 min.) : color, sound)Other title: Intestinal stem cell-mediated repair in Drosophila, part 1Subject(s): Drosophila -- Cytology | Stem cells | Drosophila melanogaster -- cytology | Drosophila melanogaster | Intestines -- cytology | Intestines -- pathology | Stem Cells -- cytology | Stem Cells -- metabolismOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: The adult Drosophila midgut contains tissue specific intestinal stem cells (ISCs) -- ISCs are the only dividing cells in the midgut and are responsible for maintaining midgut homeostasis and regeneration -- The ISC division gives rise to a renewed stem cell and an enteroblast, which can differentiate into secretory enteroendocrine cells or absorptive enterocytes -- Intrinsic factors such as Tuberous Sclerosis Complex and Myc coordinate the growth and division of ISCs -- Extrinsic factors such as Epidermal Growth Factor from surrounding cells and the interaction with basement membrane also regulate the rate of ISC division -- Insulin secreted from CNS function as a long-range growth factor to control ISC activity and therefore intestinal tissue homeostasis.
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Mode of access: World Wide Web.