Maintaining the silenced state of master regulatory genes during development [electronic resource] / Bob Kingston.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (54 min.) : color, sound)Subject(s): Chromosomal proteins | Developmental genetics | Epigenesis | Gene silencing | Genetic regulation | Drosophila Proteins -- metabolism | Epigenesis, Genetic | Gene Expression Regulation, Developmental | Gene Silencing | Polycomb-Group Proteins | Repressor Proteins -- metabolism | Transcription Factors -- metabolismOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Gene repression in cell division -- Early homeotic gene expression patterns -- The polycomb group -- Mutants of polycomb fail to maintain repression -- Transcriptional memory -- Core functional PcG complexes -- Regulation of PRC2 in drosophila and humans -- PRC2 core subunits in humans -- Prominent modifications that can occur -- Chromodomains bind H3 tail marks -- Differential chromodomain binding -- Targeting of the PcG complexes -- Drosophila PREs are bound by PHO -- Mechanisms involved in targeting -- Mammalian HOX clusters are a key PRC1 target -- Human D11.12 is similar to fly PREs -- CpG islands and long non-coding RNAs -- Small RNAs specifying repression -- Noncoding RNAs influence chromatin structure -- Mode of repression -- How are genes silenced? -- PRC1 in compaction and ubiquitylation -- Nucleosome dynamics -- Characteristics of the compaction domain -- Gene silencing by chromatin compaction -- The SIR complex and mating type silencing -- Structural rearrangements in NCP and BAH -- Folding events in Sir3 BAH/NCP complex -- The nucleosome as a silencing machinery -- Epigenetic memory.
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Mode of access: World Wide Web.