Inhibiting protein-protein interactions [electronic resource] : part 1 of 2 / Adrian Whitty.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Small molecule drug discovery: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (41 min.) : color, sound)Other title: Inhibiting protein-protein interactions. Part 1Subject(s): Drug development | Drug targeting | Protein-protein interactions | Proteins -- Inhibitors | Drug Design | Protein Binding -- drug effects | Protein Interaction Mapping | Proteins -- antagonists & inhibitors | Proteins -- metabolism | Small Molecule Libraries -- pharmacologyOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: The druggable proteome -- Objectives -- Five propositions about the druggability of PPI targets -- Classification of PPI targets -- Why are small molecule inhibitors of PPI hard to obtain? -- PPI topology can vary widely -- Classification of PPI interfaces -- Druggability -- Fragment-based lead identification -- Empirical measures of druggability -- Factors affecting druggability -- Computational assessment of PPI druggability with FTMAP -- Evaluating PPI using FTMAP -- Nature of druggable sites in PPI.
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Mode of access: World Wide Web.