Hox gene regulation in vertebrate hindbrain development [electronic resource] / Robb Krumlauf.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (59 min.) : color, sound)Subject(s): Developmental genetics | Genetic regulation | Homeobox genes | Neural crest | Rhombencephalon | Vertebrates -- Development | Vertebrates -- Evolution | Body Patterning | Gene Expression Regulation, Developmental -- physiology | Gene Regulatory Networks | Genes, Homeobox | Neural Crest | Rhombencephalon -- embryology | Rhombencephalon -- genetics | Vertebrates -- embryologyOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Origins and diversity of the basic animal body plan -- Ernst Haeckel: Anthropogenie, "Tree of life" -- Common mechanisms for vertebrate body plan -- How does diversity follow from similarity? -- Hox homeotic genes are clustered and control head to tail patterning -- Vertebrate Hox genes display co-linear and segmental expression -- "Hox code" -- Conservation of Hox genes in vertebrates -- The phylotypic stage -- The vertebrate hindbrain, head development & Hox genes: A story in segments -- The nervous system plays an important role in regulating craniofacial development through formation of neural crest cells -- Roles for hindbrain segmentation & neural crest migration in craniofacial patterning -- How are the AP patterns of Hox expression set up? -- Analysis of cis-regulation of HoxB genes -- Modular cis-regulatory control of Hoxa2 -- Vertebrate hindbrain segmentation GRN -- Regulation of vertebrate hindbrain organisation -- Previously characterized consensus Hox/Pbx binding sites -- The rhombomere 4 regulatory network -- DV patterns of Hox expression -- Segmental and neuronal functions of Hox genes -- Complex cis-regultory landscape controls Hox gene expression in the specification of axial identity -- Hox genes as integrators of morphogenic information -- Opposing signaling centers drive axial extension: Wnt and Fgf signaling oppose RA signaling -- Regulators of Hox gene expression -- What mechanisms do retinoids use to regulate Hox expression? -- Where are the RAREs and how do they function in the Hox clusters? -- HoxB multiplex reporter BAC reproduces endogenous gene expression pattern -- RAREs are necessary for anterior expansion of 5' Hoxb expression in the neural tube -- Conserved and unique RAREs in Hox clusters -- Is DE-RARE is responsible for the anterior expansion? -- DE-RARE can anteriorize 5' Hoxa gene expression -- Hox genes, retinoids and heart development -- Where are the heart regulatory regions -- Identification of novel HoxB control regions -- Novel RAREs in heart & endoderm enhancers -- Cooperative, shared, selective and long-range enhancers -- Building the gene regulatory network which governs segmental, neuronal and patterning functions of Hox genes.
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Mode of access: World Wide Web.