Adapting proteostasis to ameliorate aggregation-associated amyloid diseases [electronic resource] / Jeffery W. Kelly.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Protein folding, aggregation and design : concepts, experiments, theories and mechanisms: Publisher: London : Henry Stewart Talks, 2018Description: 1 online resource (1 streaming video file (49 min.) : color, sound)Subject(s): Amyloidosis -- Treatment | Clinical trials | Protein folding | Proteins -- Metabolism -- Disorders | Activating Transcription Factor 6 -- metabolism | Amyloid -- metabolism | Amyloidosis -- drug therapy | Clinical Trials as Topic | Diflunisal | Prealbumin | Protein Aggregates -- drug effects | Proteostasis | Unfolded Protein Response -- drug effectsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Protein folding, misfolding, aggregation -- The proteostasis network and its regulation -- Gain and loss of function diseases -- The transthyretin (TTR) amyloidosis -- Kinetic stabilizers & clinical trial results -- Tafamidis & Diflunisal: evidence for the amyloid hypothesis -- Improving protein misfolding/aggregation diseases -- The unfolded protein response (UPR) and its arm-selective activators -- ATF6 activation & reduction of TTR mutant -- Clinical trials in amyloidosis with cardiac involvement.
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Mode of access: World Wide Web.