Biased signaling at mu opioid receptor splice variants [electronic resource] / Ying-Xian Pan.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. G Protein-Coupled Receptors (GPCRs) signaling in health and disease: Publisher: London : Henry Stewart Talks, 2020Description: 1 online resource (1 streaming video file (42 min.) : color, sound)Subject(s): Cellular signal transduction | G proteins -- Receptors | Opioids -- Receptors | Alternative Splicing | Drug Tolerance | Morphine | OPRM1 protein, human | Receptors, G-Protein-Coupled -- metabolism | Receptors, Opioid, mu -- genetics | Receptors, Opioid, mu -- metabolism | Signal TransductionOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Extensive alternative pre-mRNA splicing of the mu opioid receptor gene (OPRM1) -- Distinct intracellular C-terminal tails in different full-length 7TM C-terminal variants -- Distinct in vivo functions of several C-terminal tails -- In vivo truncation of C-terminal tails encoded by E7 affects morphine tolerance and reward -- In vivo truncation of C-terminal tails encoded by E4 affects morphine tolerance and dependence.
Access restricted to subscribers.
Mode of access: World Wide Web.