Mouse models to investigate cell cycle and cancer [electronic resource] / Philipp Kaldis.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Cell division cycle : controlling when and where cells divide and differentiate: Publisher: London : Henry Stewart Talks, 2020Description: 1 online resource (1 streaming video file (62 min.) : color, sound)Subject(s): Animal models in research | Cancer -- Research | Cell cycle -- Regulation | Mice | Cell Cycle Proteins | Cell Cycle | Cell Transformation, Neoplastic | Cyclin E | Cyclin-Dependent Kinase 2 | Cyclin-Dependent Kinase 6 | Cyclin-Dependent Kinases | DNA Damage | Mice | Models, Animal | Neoplasms | Retinoblastoma Protein | S PhaseOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Updated version of a talk first published in 2009.
Contents: Cell cycle regulation during mouse development and adulthood -- Cyclin-dependent kinases (Cdks) -- The genetic pathways for cell cycle regulation -- Cdk1, Cdk2, Cdk4, and Cdk6 -- The in vivo functions of Cdk2 -- Compensation between different Cdk/cyclin complexes -- Genetic interaction between Cdk2 and Cdk4 -- Control of the G1/S phase transition by the Retinoblastoma protein (Rb) -- DNA damage response in the absence of Cdk2 -- p27Kip1 inhibits Cdk1 in vivo -- Cdk1/cyclin E complexes promote S phase -- Cdks and tumors.
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Mode of access: World Wide Web.