The endoplasmic reticulum [electronic resource] : protein folding and control of calcium homeostasis / Marek Michalak.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Endoplasmic reticulum : fundamentals and role in disease: Publisher: London : Henry Stewart Talks, 2022Description: 1 online resource (1 streaming video file (32 min.) : color, sound)Subject(s): Calcium in the body | Calcium -- Physiological effect | Endoplasmic reticulum | Protein folding | Alzheimer Disease | Calcium Channels | Calcium Signaling | Calcium -- metabolism | Calreticulin | Charcot-Marie-Tooth Disease | Cystic Fibrosis | Endoplasmic Reticulum -- metabolism | Fibrosis | Homeostasis -- physiology | Protein Folding | Stress, Physiological | Unfolded Protein Response | ursodoxicoltaurineOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Updated version of a talk first published in 2007.
Contents: Quality control -- Chaperones and folding enzymes in the ER -- Prevention of the deployment of misfolded proteins -- Impaired protein folding in Alzheimer's disease, CMT and cystic fibrosis -- Deficiency in ER calcium-binding chaperones impacts embryonic development.
Contents:Update talk: ER stress -- The Unfolded Protein Response (UPR) -- ER stress sensors -- Inositol-Requiring Element 1 (IRE1 alpha) -- Stress-induced activation of the calreticulin gene -- Targeting IRE1 alpha to prevent cardiac fibrosis -- TUDCA prevents cardiac fibrosis.
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Mode of access: World Wide Web.