The role of MAPT (Tau) in neurodegenerative disease [electronic resource] : one bullet with many triggers / Michael Hutton.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Neurodegenerative diseases : fundamentals, research methods, latest advances: Publisher: London : Henry Stewart Talks, 2022Description: 1 online resource (1 streaming video file (52 min.) : color, sound)Subject(s): Alzheimer's disease | Frontotemporal dementia | Nervous system -- Degeneration | Nervous system -- Diseases | Proteins -- Pathophysiology | tau Proteins -- adverse effects | tau Proteins -- genetics | Alzheimer Disease | Brain -- pathology | Corticobasal Degeneration | Frontotemporal Dementia | Haplotypes | Mice,Transgenic | Neurodegenerative Diseases -- genetics | Neurodegenerative Diseases -- metabolism | Neurofibrillary Tangles | Supranuclear Palsy, Progressive | Tauopathies -- pathology | Tauopathies -- therapyOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Updated version of a talk first published in 2007.
Contents: Medical importance of tauopathies -- Microtubule Associated Protein Tau (MAPT) is incorporated into neurofibrillary lesions -- Mutations in the MAPT gene give rise to Frontotemporal dementia with parkinsonism (FTDP-17) -- Common variability in the MAPT, the so-called H1/H1 haplotype and sporadic tauopathies -- Progressive supranuclear Palsy and Cortico-basal degeneration -- Constitutive and conditional transgenic mouse models of tauopathy -- The JNPL3 mouse model of tauopathy -- Neurofibrillary tau pathology in the JNPL3 mice -- A-beta and MAPT pathologies can interact during the development of Alzheimer's disease -- Conditional rTg4510 model of tauopathy -- Major mechanism of neurodegeneration in tauopathy -- Potential therapeutic applications.
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Mode of access: World Wide Web.