Drug discovery and target validation in the p53 pathway (Record no. 77744)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02279ngm a2200337 a 4500 |
| 001 - CONTROL NUMBER | |
| control field | HST2379_1_2 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | UkLoHST |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m c |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr|cna|||a|||| |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | vz|czazum |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 080121s2009 enk|||||||||||s|||v|eng d |
| 028 50 - PUBLISHER NUMBER | |
| Publisher number | 2379 |
| Source | Henry Stewart Talks |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (UkLoHST)1271 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (UkLU-K)001155637 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | UkLU-K |
| Language of cataloging | eng |
| Transcribing agency | UkLU-K |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Lane, David, |
| Dates associated with a name | 1952- |
| Relator code | spk |
| 245 10 - TITLE STATEMENT | |
| Title | Drug discovery and target validation in the p53 pathway |
| Medium | [electronic resource] / |
| Statement of responsibility, etc. | David Lane. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | London : |
| Name of publisher, distributor, etc. | Henry Stewart Talks, |
| Date of publication, distribution, etc. | 2009. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (1 streaming video file (40 min.) : |
| Other physical details | color, sound). |
| 490 1# - SERIES STATEMENT | |
| Series statement | The cell division cycle : controlling when and where cells divide and differentiate, |
| International Standard Serial Number | 2056-452X |
| 500 ## - GENERAL NOTE | |
| General note | Animated audio-visual presentation with synchonized narration. |
| 500 ## - GENERAL NOTE | |
| General note | Title from title frames. |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Contents: Controlling cancer -- p53 discovery -- Oncoproteins -- SV40, Adeno and HPV -- The p53 protein -- Incidence of genetic changes in p53 in human cancers -- What does p53 do? -- The p53 pathway is blocked in many tumor cells -- p53 and HDM2 are connected by a negative feedback loop -- Mdm2 controls p53 -- Evidence for the fine regulation of the p53 response -- How does p53 cause advanced aging? -- Therapy approaches -- Gene therapy -- Activating p53 -- Targets for p53 activation -- Small peptides block p53/HDM interaction and activate p53 -- Peptide minimization and optimization -- Nutlin 3 specificity -- Thousands of compounds can be tested for their ability to activate p53-dependent transcription -- CYC202: a cdk inhibitor in clinical trial that is a non genotoxic activator of the p53 response -- CDK inhibition -- Regulation of p53 by ubiquitin like proteins -- Stress stimuli that control the activity of p53 -- New isoforms of p53. |
| 506 ## - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Access restricted to subscribers. |
| 538 ## - SYSTEM DETAILS NOTE | |
| System details note | Mode of access: World Wide Web. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cell Cycle. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Genes, cdc. |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Henry Stewart talks. |
| Name of part/section of a work | Biomedical & life sciences collection. |
| -- | Cell division cycle : controlling when and where cells divide and differentiate. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://hstalks.com/bs/1271/">https://hstalks.com/bs/1271/</a> |
| 856 42 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://hstalks.com/bs/p/381/">https://hstalks.com/bs/p/381/</a> |
| Materials specified | Series |
No items available.