The art and science of dermal formulation development / (Record no. 72400)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05964cam a2200637Ki 4500 |
| 001 - CONTROL NUMBER | |
| control field | 9780429059872 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220531132436.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m o d |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190301s2019 flu ob 001 0 eng d |
| 040 ## - Cataloging Source | |
| -- | OCoLC-P |
| -- | eng |
| -- | rda |
| -- | pn |
| -- | OCoLC-P |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780429059872 |
| -- | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0429059876 |
| -- | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780429593482 |
| -- | (electronic bk. : Mobipocket) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0429593481 |
| -- | (electronic bk. : Mobipocket) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780429596063 |
| -- | (electronic bk. : PDF) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0429596065 |
| -- | (electronic bk. : PDF) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780429594779 |
| -- | (electronic bk. : EPUB) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0429594771 |
| -- | (electronic bk. : EPUB) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 9781138064928 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 1138064920 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)1088892375 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC-P)1088892375 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RM151 |
| Item number | .B76 2019eb |
| 072 #7 - | |
| -- | MED |
| -- | 071000 |
| -- | bisacsh |
| 072 #7 - | |
| -- | MED |
| -- | 017000 |
| -- | bisacsh |
| 072 #7 - | |
| -- | MED |
| -- | 072000 |
| -- | bisacsh |
| 072 #7 - | |
| -- | TDCW |
| -- | bicssc |
| 082 04 - | |
| -- | 615/.6 |
| -- | 23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Brown, Marc D., |
| Relator term | author. |
| 245 14 - TITLE STATEMENT | |
| Title | The art and science of dermal formulation development / |
| Statement of responsibility, etc. | Marc Brown, Adrian C. Williams. |
| 264 #1 - | |
| -- | Boca Raton, Florida : |
| -- | CRC Press, |
| -- | [2019] |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource. |
| 336 ## - | |
| -- | text |
| -- | txt |
| -- | rdacontent |
| 337 ## - | |
| -- | computer |
| -- | c |
| -- | rdamedia |
| 338 ## - | |
| -- | online resource |
| -- | cr |
| -- | rdacarrier |
| 490 0# - | |
| -- | Drugs and the pharmaceutical sciences |
| 505 0# - | |
| -- | Cover; Half Title; Series Page; Title Page; Copyright Page; Dedication; Contents; Preface; Acknowledgements; About the Authors; Chapter 1: Structure and Function of Human Skin; 1.1 Introduction; 1.2 Healthy Skin Structure and Function; 1.2.1 The Subcutaneous Fat Layer; 1.2.2 The Dermis; 1.2.2.1 Pilosebaceous Unit; 1.2.2.2 Eccrine (Sweat) Glands; 1.2.2.3 Apocrine Glands; 1.2.3 The Epidermis; 1.2.3.1 Basement Membrane; 1.2.3.2 The Stratum Basale (Stratum Germinativum or, More Commonly, Basal Layer); 1.2.3.3 The Stratum Spinosum (Spinous Layer/Prickle Cell Layer) |
| 505 8# - | |
| -- | 1.2.3.4 The Stratum Granulosum (Granular Layer)1.2.3.5 The Stratum Lucidum; 1.2.3.6 The Stratum Corneum (Horny Layer); 1.2.4 Epidermal Enzyme Systems; 1.3 Physiological Factors Affecting Transdermal and Topical Drug Delivery; 1.3.1 Gender; 1.3.2 Skin Age; 1.3.3 Body Site; 1.3.4 Race; 1.3.5 Other Factors; 1.4 Skin Microbiome; 1.5 Damaged Skin; References; Chapter 2: Theoretical Aspects of Transdermal and Topical Drug Delivery; 2.1 Terminology; 2.2 The Transdermal Permeation Process; 2.3 Permeation Pathways through the Stratum Corneum; 2.3.1 Transappendageal Transport (Shunt Route Transport) |
| 505 8# - | |
| -- | 2.3.2 Transcellular Route2.3.3 Intercellular Pathway; 2.4 Influence of Permeant Physicochemical Properties on Route of Absorption; 2.4.1 Partition Coefficient; 2.4.2 Molecular Size; 2.4.3 Solubility/Melting Point; 2.4.4 Ionisation; 2.4.5 Other Factors; 2.4.6 Biomacromolecules; 2.5 Mathematics of Skin Permeation; 2.5.1 Pseudo Steady-State Permeation (Infinite Dosing); 2.5.2 Concentration Gradient or Thermodynamic Activity?; 2.5.3 Transient Permeation (Finite Dosing); References; Chapter 3: Chemical Modulation of Topical and Transdermal Permeation; 3.1 Introduction |
| 505 8# - | |
| -- | 3.2 Chemical Modulation of Drug Flux3.2.1 Mechanisms of Chemical Penetration Enhancement; 3.2.1.1 Interaction (Disordering) of Intercellular Lipids; 3.2.1.2 Interactions within Corneocytes; 3.2.1.3 Alteration of Partitioning; 3.2.1.4 Other Mechanisms of Chemical Penetration Enhancement; 3.2.2 Common Chemical Penetration Enhancers; 3.2.2.1 Water; 3.2.2.2 Sulphoxides and Similar Chemicals; 3.2.2.3 Pyrrolidones; 3.2.2.4 Azone; 3.2.2.5 Fatty Acids; 3.2.2.6 Alcohols, Fatty Alcohols, and Glycols; 3.2.2.7 Surfactants; 3.2.2.8 Urea; 3.2.2.9 Terpenes; 3.2.2.10 Phospholipids |
| 505 8# - | |
| -- | 3.2.2.11 Amino Acid-Based Enhancers3.2.2.12 Peptides; 3.2.3 Synergy between Chemical Penetration Enhancers; 3.2.4 General Comments on Penetration Enhancers; 3.3 Permeation Retardation; 3.4 Drug and Formulation Manipulation Strategies; 3.4.1 Prodrugs; 3.4.2 Ion-Pairing; 3.4.3 Eutectic Systems/Depression of Permeant Melting Point; 3.4.4 Supersaturation; References; Chapter 4: Physical and Technological Modulation of Topical and Transdermal Drug Delivery; 4.1 Introduction; 4.2 Vesicles; 4.2.1 Liposomes; 4.2.2 Non-Ionic Surfactant Vesicles (Niosomes) |
| 520 ## - | |
| -- | The Art and Science of Dermal Formulation Development is a comprehensive guide to the theory and practice of transdermal and topical formulation development, covering preclinical studies, evaluation, and regulatory approval. It enables the reader to understand the opportunities and challenges in developing products and how risks can be mitigated. Over the last 25 years, expertise in this area has declined whilst drug delivery systems for other administration routes have developed significantly. The advantages offered by transdermal and topical drug delivery remain compelling for sectors including the pharmaceutical industry, personal care, and cosmetics. This text addresses the dearth of expertise and discusses how skin can be a route of delivery and the processes in formulation development, but how such an application is very different to that used for oral, IV, and other administration routes. |
| 588 ## - | |
| -- | OCLC-licensed vendor bibliographic record. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Transdermal medication. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Transdermal medication |
| General subdivision | Research |
| -- | Methodology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Dermatologic agents |
| General subdivision | Absorption and adsorption. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Skin |
| General subdivision | Physiology. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | MEDICAL / Pharmacology |
| Source of heading or term | bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | MEDICAL / Dermatology |
| Source of heading or term | bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | MEDICAL / Pharmacy |
| Source of heading or term | bisacsh |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Williams, A. C. |
| Fuller form of name | (Adrian C.) |
| 856 40 - | |
| -- | Taylor & Francis |
| -- | https://www.taylorfrancis.com/books/9780429059872 |
| 856 42 - | |
| -- | OCLC metadata license agreement |
| -- | http://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf |
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