Bird, A. P.
DNA methylation [electronic resource] / Adrian Bird. - London : Henry Stewart Talks, 2007. - 1 online resource (1 streaming video file (43 min.) : color, sound). - Epigenetics : concepts, theories, paradigms and mechanisms, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: DNA methylation as an epigenetic mark -- location and patterns of methylated and nonmethylated CpG sites in the vertebrate genome -- factors determining DNA methylation patterns -- association of DNA methylation with stable gene silencing, e.g. methylation of CpG islands on the inactive X-chromosome, ensures long term repression of associated genes -- recruitment of corepressors that impose a silent chromatin structure -- repulsion of transcriptional activators by methyl-CpG leading to gene silencing -- the link between human disorders, including cancer, Rett Syndrome and ICF syndrome, and defects in the DNA methylation system.
Access restricted to subscribers.
Mode of access: World Wide Web.
1028 Henry Stewart Talks
Epigenesis, Genetic.
Eukaryotic Cells.
Gene Expression Regulation.
Transcription, Genetic.
DNA methylation [electronic resource] / Adrian Bird. - London : Henry Stewart Talks, 2007. - 1 online resource (1 streaming video file (43 min.) : color, sound). - Epigenetics : concepts, theories, paradigms and mechanisms, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: DNA methylation as an epigenetic mark -- location and patterns of methylated and nonmethylated CpG sites in the vertebrate genome -- factors determining DNA methylation patterns -- association of DNA methylation with stable gene silencing, e.g. methylation of CpG islands on the inactive X-chromosome, ensures long term repression of associated genes -- recruitment of corepressors that impose a silent chromatin structure -- repulsion of transcriptional activators by methyl-CpG leading to gene silencing -- the link between human disorders, including cancer, Rett Syndrome and ICF syndrome, and defects in the DNA methylation system.
Access restricted to subscribers.
Mode of access: World Wide Web.
1028 Henry Stewart Talks
Epigenesis, Genetic.
Eukaryotic Cells.
Gene Expression Regulation.
Transcription, Genetic.