Mayer, R. J.

Ubiquitination and Alzheimer related disorders new insights and possible therapeutic approaches! / [electronic resource] : John Mayer. - London : Henry Stewart Talks, 2007. - 1 online resource (1 streaming video file (12 min.) : color, sound). - Neurodegenerative diseases : fundamentals, research methods, latest advances, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Neurodegenerative diseases : fundamentals, research methods, latest advances. .

Animated audio-visual presentation with synchronized narration. Title from title frames.

Contents: Alzheimer's disease and dementia with Lewy bodies -- Ubiquitin and the ubiquitin pathway of intracellular proteolysis -- Ubiquitin immunocytochemistry in understanding chronic neurodegenerative disease -- Ubiquitin and the discovery of dementia with Lewy bodies -- Importance of ubiquitin for normal brain functions -- Ubiquitin and Parkinson's disease -- Intraneuronal protein aggregation and neurodegenerative disease -- Experimental demonstration of generic gene expression changes in response to protein aggregates -- Expression of the mitogen activated protein kinase (MEK5) -- ERK5 kinase module in Alzheimer's disease and dementia with Lewy bodies -- Ubiquitin-p62-MEK5/ERK5 pathway of neuronal survival in Alzheimer related disorders -- Diagnostic and therapeutic importance of ubiquitin/kinase mediated neuronal survival and anti-apoptotic pathways.

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1050 Henry Stewart Talks


Alzheimer Disease.
Neurodegenerative Diseases.
Ubiquitin--therapeutic use.
Ubiquitination.
Technical University of Mombasa
Tom Mboya Street, Tudor 90420-80100 , Mombasa Kenya
Tel: (254)41-2492222/3 Fax: 2490571