Babu, M. Madan,
Intrinsically unstructured proteins regulation and disease / [electronic resource] : M. Madan Babu. - London : Henry Stewart Talks, 2012. - 1 online resource (1 streaming video file (36 min.) : color, sound). - Protein homeostasis : folding proteins and maintaining the protein-protein interaction networks, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Protein homeostasis. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Regulatory genomics and systems biology -- Intrinsically unstructured proteins (IUPs): structural and biophysical advantage -- Functional advantage -- Thermodynamic and kinetic advantage -- Conformational advantage -- Identification of IUPs -- Functions of IUPs -- Disadvantages of unstructured regions -- Unstructured regions in proteins -- Cells minimize the risks of unstructured proteins -- Tight regulation of IUPs -- Key regulatory events affecting protein availability -- IUPs in yeast -- Gene-ontology functional enrichment analysis -- Genome-scale datasets on transcript availability -- Transcripts encoding IUPs are tightly controlled -- Mechanisms affecting transcript stability -- Genome-scale datasets on protein availability -- IUPs are tightly controlled at the translational level -- PEST sequences -- Aggregation prone IUPs: more tightly regulated -- Control calculation -- Tight regulation of IUPs is evolutionarily conserved -- Control of IUP affects signaling fidelity/regulation -- Control of specific IUP affects protein aggregation.
Access restricted to subscribers.
Mode of access: World Wide Web.
3184 Henry Stewart Talks
Genetic regulation.
Protein folding.
Gene Expression Regulation.
Protein Conformation.
Protein Folding.
Transcription Factors--genetics.
Intrinsically unstructured proteins regulation and disease / [electronic resource] : M. Madan Babu. - London : Henry Stewart Talks, 2012. - 1 online resource (1 streaming video file (36 min.) : color, sound). - Protein homeostasis : folding proteins and maintaining the protein-protein interaction networks, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Protein homeostasis. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Regulatory genomics and systems biology -- Intrinsically unstructured proteins (IUPs): structural and biophysical advantage -- Functional advantage -- Thermodynamic and kinetic advantage -- Conformational advantage -- Identification of IUPs -- Functions of IUPs -- Disadvantages of unstructured regions -- Unstructured regions in proteins -- Cells minimize the risks of unstructured proteins -- Tight regulation of IUPs -- Key regulatory events affecting protein availability -- IUPs in yeast -- Gene-ontology functional enrichment analysis -- Genome-scale datasets on transcript availability -- Transcripts encoding IUPs are tightly controlled -- Mechanisms affecting transcript stability -- Genome-scale datasets on protein availability -- IUPs are tightly controlled at the translational level -- PEST sequences -- Aggregation prone IUPs: more tightly regulated -- Control calculation -- Tight regulation of IUPs is evolutionarily conserved -- Control of IUP affects signaling fidelity/regulation -- Control of specific IUP affects protein aggregation.
Access restricted to subscribers.
Mode of access: World Wide Web.
3184 Henry Stewart Talks
Genetic regulation.
Protein folding.
Gene Expression Regulation.
Protein Conformation.
Protein Folding.
Transcription Factors--genetics.