Klein, William L.,
Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease / [electronic resource] : Amyloid beta oligomers : pathogenic ligands that attack dendritic spines Aß oligomers : pathogenic ligands that attack dendritic spines Targeting AB oligomers Targeting amyloid beta oligomers William L. Klein. - London : Henry Stewart Talks, 2014. - 1 online resource (1 streaming video file (68 min.) : color, sound). - Drug discovery and development in the neurosciences, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Drug discovery and development in the neurosciences. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.
Access restricted to subscribers.
Mode of access: World Wide Web.
3594 Henry Stewart Talks
Alzheimer's disease--Chemotherapy.
Alzheimer's disease--Diagnosis.
Alzheimer's disease--Pathogenesis.
Amyloid beta-protein.
Nervous system--Degeneration.
Alzheimer Disease--drug therapy.
Alzheimer Disease--etiology.
Alzheimer Disease--metabolism.
Alzheimer Disease--pathology.
Amyloid beta-Peptides--metabolism.
Brain--metabolism.
Neurodegenerative Diseases--metabolism.
Neurons--metabolism.
Neurons--pathology.
Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease / [electronic resource] : Amyloid beta oligomers : pathogenic ligands that attack dendritic spines Aß oligomers : pathogenic ligands that attack dendritic spines Targeting AB oligomers Targeting amyloid beta oligomers William L. Klein. - London : Henry Stewart Talks, 2014. - 1 online resource (1 streaming video file (68 min.) : color, sound). - Drug discovery and development in the neurosciences, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Drug discovery and development in the neurosciences. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.
Access restricted to subscribers.
Mode of access: World Wide Web.
3594 Henry Stewart Talks
Alzheimer's disease--Chemotherapy.
Alzheimer's disease--Diagnosis.
Alzheimer's disease--Pathogenesis.
Amyloid beta-protein.
Nervous system--Degeneration.
Alzheimer Disease--drug therapy.
Alzheimer Disease--etiology.
Alzheimer Disease--metabolism.
Alzheimer Disease--pathology.
Amyloid beta-Peptides--metabolism.
Brain--metabolism.
Neurodegenerative Diseases--metabolism.
Neurons--metabolism.
Neurons--pathology.