Alon, Uri, 1969-
Evolutionary tradeoffs and the geometry of gene expression space [electronic resource] / Uri Alon. - London : Henry Stewart Talks, 2014. - 1 online resource (1 streaming video file (36 min.) : color, sound). - Systems biology, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Systems biology. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Organisms, tissues and molecules often need to perform multiple tasks -- Usually no phenotype can be optimal at all tasks at once which leads to a fundamental tradeoff -- We study this using the concept of Pareto optimality from engineering and economics -- Tradeoffs lead to an unexpected simplicity in the range of optimal phenotypes; they fall on low dimensional shapes in trait space such as lines, triangles and tetrahedrons -- At the vertices of these polygons are phenotypes that specialize at a single task -- We demonstrate this using data from animal and fossil morphology, bacterial gene expression and other biological systems.
Access restricted to subscribers.
Mode of access: World Wide Web.
3787 Henry Stewart Talks
Bioinformatics.
Biological models.
Evolution (Biology)
Gene expression.
Mathematical optimization.
Molecular biology.
Morphology (Animals)
Phenotype.
Beak--anatomy & histology.
Biological Evolution.
Computational Biology.
Evolution, Molecular.
Fossils--anatomy & histology.
Gene Expression.
Genes, Bacterial.
Genetic Fitness.
Models, Biological.
Models, Statistical.
Phenotype.
Selection, Genetic.
Systems Biology.
Evolutionary tradeoffs and the geometry of gene expression space [electronic resource] / Uri Alon. - London : Henry Stewart Talks, 2014. - 1 online resource (1 streaming video file (36 min.) : color, sound). - Systems biology, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Systems biology. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Organisms, tissues and molecules often need to perform multiple tasks -- Usually no phenotype can be optimal at all tasks at once which leads to a fundamental tradeoff -- We study this using the concept of Pareto optimality from engineering and economics -- Tradeoffs lead to an unexpected simplicity in the range of optimal phenotypes; they fall on low dimensional shapes in trait space such as lines, triangles and tetrahedrons -- At the vertices of these polygons are phenotypes that specialize at a single task -- We demonstrate this using data from animal and fossil morphology, bacterial gene expression and other biological systems.
Access restricted to subscribers.
Mode of access: World Wide Web.
3787 Henry Stewart Talks
Bioinformatics.
Biological models.
Evolution (Biology)
Gene expression.
Mathematical optimization.
Molecular biology.
Morphology (Animals)
Phenotype.
Beak--anatomy & histology.
Biological Evolution.
Computational Biology.
Evolution, Molecular.
Fossils--anatomy & histology.
Gene Expression.
Genes, Bacterial.
Genetic Fitness.
Models, Biological.
Models, Statistical.
Phenotype.
Selection, Genetic.
Systems Biology.