Deininger, Michael W.

CML genetic paradigm of targeted therapy, part 1 of 2 / [electronic resource] : Chronic myeloid leukemia : genetic paradigm of targeted therapy. Part 1 CML : genetic paradigm of targeted therapy. Part 1 Michael W. Deininger. - London : Henry Stewart Talks, 2015. - 1 online resource (1 streaming video file (24 min.) : color, sound). - Cancer genetics, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Cancer genetics. .

Animated audio-visual presentation with synchronized narration. Title from title frames.

Contents: Typical clinical findings and phases of chronic myeloid leukaemia (CML) -- Philadelphia chromosome (juxtaposition & genomic anatomy BCR-ABL1) -- Target cells for transformation -- Molecular driver for pathogenesis (BCR-ABL1 tyrosine kinase) -- Imatinib (inhibitor of BCR-ABL1).

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Mode of access: World Wide Web.

4040 Henry Stewart Talks


Antineoplastic agents.
Cancer--Genetic aspects.
Chronic myeloid leukemia.
Drug delivery systems.
Protein kinases--Inhibitors.
Antineoplastic Agents--pharmacology.
Drug Delivery Systems.
Fusion Proteins, bcr-abl--antagonists & inhibitors.
imatinib.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive--drug therapy.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive--genetics.
Molecular Targeted Therapy--methods.
Philadelphia Chromosome--drug effects.
Protein Kinase Inhibitors.
Protein-Tyrosine Kinases--antagonists & inhibitors.
Translocation, Genetic.
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