Hell, Johannes, 1985-

β2 adrenergic receptor complexes mediate localized cAMP signaling [electronic resource] / Beta2 adrenergic receptor complexes mediate localized cAMP signaling Johannes W. Hell. - London : Henry Stewart Talks, 2018. - 1 online resource (1 streaming video file (43 min.) : color, sound). - Ion channels : mediators of ion currents across cell membranes, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Ion channels. .

Animated audio-visual presentation with synchronized narration. Title from title frames. Updated version of a talk first published in 2011 under the title: Beta-adrenergic receptor - ion channel signaling complexes.

Contents: Introduction to signaling by beta adrenergic receptors and the corresponding regulation of the L-type calcium channel Cav1.2 in brain and heart -- Cav1.2 signaling complex in brain -- Role of the beta2 adrenergic receptor, Cav1.2, and their association in beta adrenergic signaling in the brain and in synaptic plasticity -- Introduction to the signaling complex formed by the beta2 adrenergic receptor with the AMPA-type glutamate receptor (AMPAR) -- AMPAR signaling complex in brain -- Conclusion: formation of a functional unit between the AMPAR and Cav1.2 whose activity is driven by beta2 adrenergic stimulation to augment synaptic strength in a lasting manner.

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2842 Henry Stewart Talks


Beta adrenoceptors.
Calcium channels.
Cardiovascular system--Physiology.
Cellular signal transduction.
Central nervous system--Molecular aspects.
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid.
Calcium Channels, L-Type--physiology.
Cyclic AMP.
Neuronal Plasticity.
Neurons--physiology.
Receptors, Adrenergic, beta-2--metabolism.
Receptors, Adrenergic, beta-2--physiology.
Receptors, AMPA.
Receptors, Glutamate.
Signal Transduction--physiology.
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