Matharu, Navneet,
Modulating gene expression to treat diseases [electronic resource] / Navneet Matharu. - London : Henry Stewart Talks, 2021. - 1 online resource (1 streaming video file (20 min.) : color, sound). - The biomedical & life sciences collection, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Programmable DNA targeting modules -- Effector domain functions and possibilities -- Haploinsufficiency and its role in disease -- CRISPRa targeting strategy to rescue Sim1 obesity -- CRISPRa targeting strategy to treat Mc4r haploinsufficiency.
Access restricted to subscribers.
Mode of access: World Wide Web.
5594 Henry Stewart Talks
CRISPR (Genetics)
Gene expression.
Gene targeting.
Gene therapy.
Medical genetics.
Molecular genetics.
Basic Helix-Loop-Helix Transcription Factors.
Clustered Regularly Interspaced Short Palindromic Repeats.
CRISPR-Cas Systems.
Gene Expression Regulation.
Gene Targeting--methods.
Genetic Diseases, Inborn--therapy.
Haploinsufficiency.
Loss of Function Mutation.
Obesity--genetics.
Obesity--therapy.
Receptor, Melanocortin, Type 4.
Repressor Proteins.
Up-Regulation.
Modulating gene expression to treat diseases [electronic resource] / Navneet Matharu. - London : Henry Stewart Talks, 2021. - 1 online resource (1 streaming video file (20 min.) : color, sound). - The biomedical & life sciences collection, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. .
Animated audio-visual presentation with synchronized narration. Title from title frames.
Contents: Programmable DNA targeting modules -- Effector domain functions and possibilities -- Haploinsufficiency and its role in disease -- CRISPRa targeting strategy to rescue Sim1 obesity -- CRISPRa targeting strategy to treat Mc4r haploinsufficiency.
Access restricted to subscribers.
Mode of access: World Wide Web.
5594 Henry Stewart Talks
CRISPR (Genetics)
Gene expression.
Gene targeting.
Gene therapy.
Medical genetics.
Molecular genetics.
Basic Helix-Loop-Helix Transcription Factors.
Clustered Regularly Interspaced Short Palindromic Repeats.
CRISPR-Cas Systems.
Gene Expression Regulation.
Gene Targeting--methods.
Genetic Diseases, Inborn--therapy.
Haploinsufficiency.
Loss of Function Mutation.
Obesity--genetics.
Obesity--therapy.
Receptor, Melanocortin, Type 4.
Repressor Proteins.
Up-Regulation.